Document Type

Journal Article

Publication Title

Pilot and Feasibility Studies






BMC / Springer Nature


Exercise Medicine Research Institute




Australian New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP) Commonwealth Research Training Programme scholarship Freemasons Centre for Men's Health National Health and Medical Research Council Victorian Cancer Agency Mid-Career Fellowship

Grant Number

NHMRC Number : 1090517

Grant Link


Evans, H. E. L., Forbes, C. C., Galvão, D. A., Vandelanotte, C., Newton, R. U., Wittert, G., ... Short, C. E. (2021). Evaluating a web-and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (exerciseguide): Protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 7(21).


© 2021, The Author(s). Introduction: Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain the benefits. There are many barriers, which limit the uptake of face-to-face exercise in this population including lack of suitable facilities, remoteness, and access to experts, significant fatigue, urinary incontinence and motivation. Technology-enabled interventions offer a distance-based alternative. This protocol describes a pilot two-armed randomised controlled study that will investigate the feasibility and preliminary efficacy of an online exercise and behavioural change tool (ExerciseGuide) amongst individuals with metastatic prostate cancer. Methods: Sixty-six participants with histologically diagnosed metastatic prostate cancer will be randomised into either the 8-week intervention or a wait-list control. The intervention arm will have access to a tailored website, remote supervision, and tele-coaching sessions to enhance support and adherence. Algorithms will individually prescribe resistance and aerobic exercise based upon factors such as metastasis location, pain, fatigue, confidence and current exercise levels. Behavioural change strategies and education on exercise benefits, safety and lifestyle are also tailored through the website. The primary outcome will be intervention feasibility (safety, usability, acceptability, and adherence). Secondary exploratory outcomes include changes in physical activity, quality of life, sleep, and physical function. Outcomes will be measured at baseline and week 9. Discussion: The study aims to determine the potential feasibility of an online remotely monitored exercise intervention developed for individuals with metastatic prostate cancer. If feasible, this pilot intervention will inform the design and implementation of further distance-based interventions. Trial registration: ANZCTR, ACTRN12614001268639. Registered 10 December 2018,



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Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.