Dominantly Inherited Alzheimer Network: Facilitating Research And Clinical Trials
Authors
John Morris
Paul S. Aisen
Randall J. Bateman
Tammie L. Benzinger
Nigel J. Cairns
Anne M. Fagan
Bernardino Ghetti
Alison M. Goate
David M. Holtzman
William E. Klunk
Eric McDade
Daniel S. Marcus
Ralph Martins, Edith Cowan UniversityFollow
Colin Masters
Richard Mayeux
Angela Oliver
Kimberly Quaid
John M. Ringman
Martin N. Rossor
Stephen Salloway
Peter R. Schofield
Natalie J. Selsor
Reisa A. Sperling
Michael W. Weiner
Chengjie Xiong
Krista L. Moulder
Virginia D. Buckles
Document Type
Journal Article
Publisher
Future Science Group
Faculty
Faculty of Health, Engineering and Science
School
School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care
Abstract
The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer’s Disease (AD) Centers that are conducting a multifaceted prospective biomarker study in individuals at risk for autosomal dominant AD. The DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic autosomal dominant AD mutation carriers and their noncarrier family members to determine the pathochronology of clinical, cognitive, neuroimaging and fluid biomarkers of AD. This article describes the structure, implementation and underlying principles of the DIAN, as well as the demographic features of the initial DIAN cohort.
DOI
10.4155/cli.12.93
Access Rights
subscription content
Comments
Morris, J. C., Aisen, P. S., Bateman, R. J., Benzinger, T. L., Cairns, N. J., Fagan, A. M., ... & Buckles, V. D. (2012). Developing an international network for Alzheimer's research: the Dominantly Inherited Alzheimer Network. Clinical investigation, 2(10), 975-984. Original article is available here