Dominantly Inherited Alzheimer Network: Facilitating Research And Clinical Trials

Authors

• John Morris
• Paul S. Aisen
• Randall J. Bateman
• Tammie L. Benzinger
• Nigel J. Cairns
• Anne M. Fagan
• Bernardino Ghetti
• Alison M. Goate
• David M. Holtzman
• William E. Klunk
• Eric McDade
• Daniel S. Marcus
• Ralph Martins, Edith Cowan UniversityFollow
• Colin Masters
• Richard Mayeux
• Angela Oliver
• Kimberly Quaid
• John M. Ringman
• Martin N. Rossor
• Stephen Salloway
• Peter R. Schofield
• Natalie J. Selsor
• Reisa A. Sperling
• Michael W. Weiner
• Chengjie Xiong
• Krista L. Moulder
• Virginia D. Buckles

Document Type

Journal Article

Keywords

Alzheimer, Dominantly Inherited Alzheimer Network

Publisher

Future Science Group

Faculty

Faculty of Health, Engineering and Science

School

School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care

Comments

Morris, J. C., Aisen, P. S., Bateman, R. J., Benzinger, T. L., Cairns, N. J., Fagan, A. M., ... & Buckles, V. D. (2012). Developing an international network for Alzheimer's research: the Dominantly Inherited Alzheimer Network. Clinical investigation, 2(10), 975-984. Original article is available here

Abstract

The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer’s Disease (AD) Centers that are conducting a multifaceted prospective biomarker study in individuals at risk for autosomal dominant AD. The DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic autosomal dominant AD mutation carriers and their noncarrier family members to determine the pathochronology of clinical, cognitive, neuroimaging and fluid biomarkers of AD. This article describes the structure, implementation and underlying principles of the DIAN, as well as the demographic features of the initial DIAN cohort.

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