Dominantly Inherited Alzheimer Network: Facilitating Research And Clinical Trials

Document Type



Future Science Group


Faculty of Health, Engineering and Science


School of Medical Sciences, Centre of Excellence for Alzheimer's Disease Research & Care


This article was originally published as : Morris, J. C., Aisen, P. S., Bateman, R. J., Benzinger, T. L., Cairns, N. J., Fagan, A. M., ... & Buckles, V. D. (2012). Developing an international network for Alzheimer's research: the Dominantly Inherited Alzheimer Network. Clinical investigation, 2(10), 975-984. Original article is available here


The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer’s Disease (AD) Centers that are conducting a multifaceted prospective biomarker study in individuals at risk for autosomal dominant AD. The DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic autosomal dominant AD mutation carriers and their noncarrier family members to determine the pathochronology of clinical, cognitive, neuroimaging and fluid biomarkers of AD. This article describes the structure, implementation and underlying principles of the DIAN, as well as the demographic features of the initial DIAN cohort.