Document Type

Journal Article

Publication Title

Molecules

Volume

29

Issue

6

PubMed ID

38542917

Publisher

MDPI

School

Centre for Precision Health

RAS ID

70002

Funders

National Key Research and Development Program of China / European Commission Horizon 2020 / Beijing Talents Project

Comments

Sun, W., Jian, X., Zhang, J., Meng, X., Wang, H., Zheng, D., . . . Wang, Y. (2024). The causality between human immunoglobulin g (IgG) n-glycosylation and aging: A mendelian randomization study. Molecules, 29(6), article 1281. https://doi.org/10.3390/molecules29061281

Abstract

Background: Immunoglobulin G (IgG) N-glycosylation is considered a potential biomarker for aging and various pathological conditions. However, whether these changes in IgG N-glycosylation are a consequence or a contributor to the aging process remains unclear. This study aims to investigate the causality between IgG N-glycosylation and aging using Mendelian randomization (MR) analysis. Methods: We utilized genetic variants associated with IgG N-glycosylation traits, the frailty index (FI), and leukocyte telomere length (LTL) from a previous genome-wide association study (GWAS) on individuals of European ancestry. Two-sample and multivariable MR analyses were conducted, employing the inverse-variance weighted (IVW) method. Sensitivity analyses were performed to assess potential confounding factors. Results: Using the IVW method, we found suggestive evidence of a causal association between GP14 and FI ( 0.026, 95% CI 0.003 to 0.050, p = 0.027) and LTL ( −0.020, 95% CI −0.037 to −0.002, p = 0.029) in the two-sample MR analysis. In the multivariable MR analysis, suggestive evidence was found for GP23 and FI ( −0.119, 95% CI −0.219 to −0.019, p = 0.019) and GP2 and LTL ( 0.140, 95% CI 0.020 to 0.260, p = 0.023). Conclusions: In conclusion, our results supported a potentially causal effect of lower GP23 levels on an advanced aging state. Additional verification is required to further substantiate the causal relationship between glycosylation and aging.

DOI

10.3390/molecules29061281

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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