Abstract
Background: Immunoglobulin G (IgG) N-glycosylation is considered a potential biomarker for aging and various pathological conditions. However, whether these changes in IgG N-glycosylation are a consequence or a contributor to the aging process remains unclear. This study aims to investigate the causality between IgG N-glycosylation and aging using Mendelian randomization (MR) analysis. Methods: We utilized genetic variants associated with IgG N-glycosylation traits, the frailty index (FI), and leukocyte telomere length (LTL) from a previous genome-wide association study (GWAS) on individuals of European ancestry. Two-sample and multivariable MR analyses were conducted, employing the inverse-variance weighted (IVW) method. Sensitivity analyses were performed to assess potential confounding factors. Results: Using the IVW method, we found suggestive evidence of a causal association between GP14 and FI ( 0.026, 95% CI 0.003 to 0.050, p = 0.027) and LTL ( −0.020, 95% CI −0.037 to −0.002, p = 0.029) in the two-sample MR analysis. In the multivariable MR analysis, suggestive evidence was found for GP23 and FI ( −0.119, 95% CI −0.219 to −0.019, p = 0.019) and GP2 and LTL ( 0.140, 95% CI 0.020 to 0.260, p = 0.023). Conclusions: In conclusion, our results supported a potentially causal effect of lower GP23 levels on an advanced aging state. Additional verification is required to further substantiate the causal relationship between glycosylation and aging.
Document Type
Journal Article
Date of Publication
3-1-2024
Volume
29
Issue
6
PubMed ID
38542917
Publication Title
Molecules
Publisher
MDPI
School
Centre for Precision Health
RAS ID
70002
Funders
National Key Research and Development Program of China / European Commission Horizon 2020 / Beijing Talents Project
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Sun, W., Jian, X., Zhang, J., Meng, X., Wang, H., Zheng, D., . . . Wang, Y. (2024). The causality between human immunoglobulin g (IgG) n-glycosylation and aging: A mendelian randomization study. Molecules, 29(6), article 1281. https://doi.org/10.3390/molecules29061281