The relationship between diet, depression, and Alzheimer's disease: A narrative review

Authors

Hilal Salim Said Al Shamsi, Edith Cowan UniversityFollow
Stephanie R. Rainey-Smith, Edith Cowan UniversityFollow
Samantha L. Gardener, Edith Cowan UniversityFollow
Hamid R. Sohrabi, Edith Cowan UniversityFollow
Rodrigo Canovas
Ralph N. Martins, Edith Cowan UniversityFollow
Warnakulasuriya Mary Ann Dipika Binosha Fernando, Edith Cowan UniversityFollow

Document Type

Journal Article

Publication Title

Molecular Nutrition and Food Research

Volume

68

Issue

13

PubMed ID

38973221

Publisher

Wiley

School

Centre of Excellence for Alzheimer's Disease Research and Care / School of Medical and Health Sciences

RAS ID

71190

Funders

National Health and Medical Research Council / Omani Consulate

Grant Number

GNT1197315

Comments

Al Shamsi, H. S. S., Rainey‐Smith, S. R., Gardener, S. L., Sohrabi, H. R., Canovas, R., Martins, R. N., & Fernando, W. M. A. D. B. (2024). The relationship between diet, depression, and Alzheimer's disease: A narrative review. Molecular Nutrition & Food Research, 68(13). https://doi.org/10.1002/mnfr.202300419

Abstract

Purpose of Review: This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings: AD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, along with adherence to dietary patterns like the Mediterranean diet, which includes multiple beneficial dietary factors. Summary: The investigation of dietary factors in the prevention of depression and AD is a comparatively young field of research. Comprehensive highly characterised longitudinal datasets and advanced analytical approaches are required to further examine the complex relationship between diet, depression, and AD. There is a critical need for more research in this area to develop effective preventive strategies aimed at maintaining mental and physical health with advancing age.

DOI

10.1002/mnfr.202300419

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