Abstract

Purpose of Review: This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings: AD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, along with adherence to dietary patterns like the Mediterranean diet, which includes multiple beneficial dietary factors. Summary: The investigation of dietary factors in the prevention of depression and AD is a comparatively young field of research. Comprehensive highly characterised longitudinal datasets and advanced analytical approaches are required to further examine the complex relationship between diet, depression, and AD. There is a critical need for more research in this area to develop effective preventive strategies aimed at maintaining mental and physical health with advancing age.

RAS ID

71190

Document Type

Journal Article

Date of Publication

7-1-2024

Volume

68

Issue

13

Funding Information

National Health and Medical Research Council / Omani Consulate

PubMed ID

38973221

School

Centre of Excellence for Alzheimer's Disease Research and Care / School of Medical and Health Sciences

Grant Number

NHMRC Number : GNT1197315

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Publisher

Wiley

Identifier

Stephanie R. Rainey-Smith

https://orcid.org/0000-0001-7328-9624

Samantha L. Gardener

https://orcid.org/0000-0002-1933-5260

Hamid R. Sohrabi

https://orcid.org/0000-0001-8017-8682

Ralph N. Martins

https://orcid.org/0000-0002-4828-9363

Warnakulasuriya Mary Ann Dipika Binosha Fernando

https://orcid.org/0000-0002-8364-7808

Comments

Al Shamsi, H. S. S., Rainey‐Smith, S. R., Gardener, S. L., Sohrabi, H. R., Canovas, R., Martins, R. N., & Fernando, W. M. A. D. B. (2024). The relationship between diet, depression, and Alzheimer's disease: A narrative review. Molecular Nutrition & Food Research, 68(13). https://doi.org/10.1002/mnfr.202300419

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Link to publisher version (DOI)

10.1002/mnfr.202300419