Abstract
Objectives: There are currently 29 genome regions that demonstrate associations with Alzheimer's disease (AD) risk. Regular physical exercise can promote systemic change in gene expression and may modify the risk of cognitive decline and AD. This study is a secondary analysis of a randomised controlled trial and examines the effect of a six-month exercise intervention versus control on AD-related gene expression. Design: Single-site parallel pilot randomised controlled trial. Methods: 91 cognitively unimpaired older adults were enrolled in the Intense Physical Activity and Cognition (IPAC) study. Participants were randomised into one of three groups: high-intensity exercise, moderate-intensity exercise, or inactive control for six months. Blood samples were collected prior to, and within two weeks of intervention completion, for later expression analysis of 96 genes. To explore the relationship between changes in gene expression and the intervention groups, an interaction term (“time point × intervention group”) was subsequently used. Results: There were no significant differences in gene expression between the three intervention groups at baseline, nor after the intervention. Within groups, five genes were upregulated, seven were downregulated and the remainder remained unchanged. None of the examined genes showed significant change from pre- to post-intervention in the exercise groups compared to the control. Conclusions: Exercise does not change AD-related gene expression in cognitively unimpaired older adults. Several gene expression targets have been identified for further study.
Keywords
Aerobic training, Dementia, Genetics, Messenger RNA
Document Type
Journal Article
Date of Publication
1-1-2024
Volume
27
Issue
12
Publication Title
Journal of Science and Medicine in Sport
Publisher
Elsevier
School
Centre for Precision Health
RAS ID
71691
Funding Information
Funding for this research was provided by a National Health and Medical Research Council Dementia Research Development Fellowship awarded to Belinda M. Brown (grant number: GNT1097105) and a Brain Foundation research grant (no grant number) awarded to Belinda M. Brown, Simon M. Laws, and Jeremiah J. Peiffer.
Funding received from the National Health and Medical Research Council (NHMRC)
GNT1097105
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Content Type
Full object
First Page
828
Last Page
833
Recommended Citation
Marston, K. J., De Frutos-Lucas, J., Porter, T., Milicic, L., Vacher, M., Sewell, K. R., Peiffer, J. J., Laws, S. M., & Brown, B. M. (2024). Exploration of Alzheimer's disease-related gene expression following high-intensity and moderate-intensity exercise interventions. Journal of Science and Medicine in Sport, 27(12), 828-833. https://doi.org/10.1016/j.jsams.2024.07.017
Comments
Marston, K. J., De Frutos-Lucas, J., Porter, T., Milicic, L., Vacher, M., Sewell, K. R., Peiffer, J. J., Laws, S. M., & Brown, B. M. (2024). Exploration of Alzheimer's disease-related gene expression following high-intensity and moderate-intensity exercise interventions. Journal of Science and Medicine in Sport, 27(12), 828-833. https://doi.org/10.1016/j.jsams.2024.07.017