Document Type

Journal Article

Publication Title

Pancreas

Volume

50

Issue

3

Publisher

Wolters Kluwer

School

School of Medical and Health Sciences / Exercise Medicine Research Institute / Graduate Research

RAS ID

35603

Comments

Luo, H., Galvão, D. A., Newton, R. U., Lopez, P., Tang, C., Fairman, C. M., … Taaffe, D. R. (2021). Exercise medicine in the management of pancreatic cancer: A systematic review. Pancreas, 50(3), 280-292. https://doi.org/10.1097/MPA.0000000000001753

Abstract

The aim of this study was to examine the health-related effects of exercise in patients with pancreatic cancer (PanCa) through a systematic review of current evidence. Studies were obtained through searching PubMed, Web of Science, PsycINFO, Embase, CINAHL Plus, and Cochrane Library databases with additional hand searches. All intervention-based studies were included if it involved (1) adult patients with PanCa, (2) exercise training, and (3) findings in quality of life, cancer-related fatigue, psychological distress, and physical function. The review protocol was registered in PROSPERO: CRD42020154684. Seven trials described in 9 publications were included consisting of 201 patients with early-stage and advanced PanCa. Participants were required to perform supervised and/or home-based, low- to moderate-intensity resistance and/or aerobic exercise for 12 to 35 weeks or duration of neoadjuvant therapy. There were no exercise-related adverse events with a reported retention rate of 71% to 90% and exercise attendance of 64% to 96%. The programs were consistently associated with improvements in cancer-related fatigue, psychological distress, and physical function, with mixed effects on quality of life. Exercise training seems to be safe and feasible and may have a beneficial effect on various physical and psychological outcomes in patients with PanCa. Further work with rigorous study designs is required to consolidate and advance current findings.

DOI

10.1097/MPA.0000000000001753

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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