Exercise medicine in the management of pancreatic cancer: A systematic review

Authors

Hao Luo, Edith Cowan UniversityFollow
Daniel A. Galvão, Edith Cowan UniversityFollow
Robert U. Newton, Edith Cowan UniversityFollow
Pedro Lopez Da Cruz, Edith Cowan UniversityFollow
Colin Tang, Edith Cowan UniversityFollow
Ciaran M. Fairman, Edith Cowan UniversityFollow
Nigel Spry, Edith Cowan UniversityFollow
Dennis R. Taaffe, Edith Cowan UniversityFollow

Document Type

Journal Article

Publication Title

Pancreas

Volume

50

Issue

3

Publisher

Wolters Kluwer

School

School of Medical and Health Sciences / Exercise Medicine Research Institute / Graduate Research

RAS ID

35603

Comments

Luo, H., Galvão, D. A., Newton, R. U., Lopez, P., Tang, C., Fairman, C. M., … Taaffe, D. R. (2021). Exercise medicine in the management of pancreatic cancer: A systematic review. Pancreas, 50(3), 280-292. https://doi.org/10.1097/MPA.0000000000001753

Abstract

The aim of this study was to examine the health-related effects of exercise in patients with pancreatic cancer (PanCa) through a systematic review of current evidence. Studies were obtained through searching PubMed, Web of Science, PsycINFO, Embase, CINAHL Plus, and Cochrane Library databases with additional hand searches. All intervention-based studies were included if it involved (1) adult patients with PanCa, (2) exercise training, and (3) findings in quality of life, cancer-related fatigue, psychological distress, and physical function. The review protocol was registered in PROSPERO: CRD42020154684. Seven trials described in 9 publications were included consisting of 201 patients with early-stage and advanced PanCa. Participants were required to perform supervised and/or home-based, low- to moderate-intensity resistance and/or aerobic exercise for 12 to 35 weeks or duration of neoadjuvant therapy. There were no exercise-related adverse events with a reported retention rate of 71% to 90% and exercise attendance of 64% to 96%. The programs were consistently associated with improvements in cancer-related fatigue, psychological distress, and physical function, with mixed effects on quality of life. Exercise training seems to be safe and feasible and may have a beneficial effect on various physical and psychological outcomes in patients with PanCa. Further work with rigorous study designs is required to consolidate and advance current findings.

DOI

10.1097/MPA.0000000000001753

Related Publications

Luo, H. (2023). Exercise and sport medicine during chemo(radio)therapy in patients with pancreatic cancer. https://ro.ecu.edu.au/theses/2680

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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.