Testosterone Replacement Therapy In Older Male Subjective Memory Complainers: Double-blind Randomized Crossover Placebo-controlled Clinical Trial Of Physiological Assessment And Safety

Document Type

Journal Article


Bentham Science Publishers B.V.


Faculty of Health, Engineering and Science


School of Medical Sciences, Centre of Excellence for Alzheimer's Disease Research And Care




Originally published as : R Asih, P., J Wahjoepramono, E., Aniwiyanti, V., K Wijaya, L., de Ruyck, K., Taddei, K., ... & Carruthers, M. (2015). Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 14(5), 576-586. Original article available here


Testosterone replacement therapy (TRT) has been investigated in older men as a preventative treatment against Alzheimer’s disease and dementia. However, previous studies have been contradictory. We assessed TRT physiological effects in 44 older men (aged 61 ± 7.7 years) with subjective memory complaints using a double blind, randomized, crossover, placebo-controlled study. Participants were randomized into 2 groups, one group received transdermal testosterone (50 mg) daily for 24 weeks, followed by a 4 week wash-out period, then 24 weeks of placebo; the other group received the reverse treatment. Blood evaluation revealed significant increases in total testosterone, free (calculated) testosterone, dihydrotestosterone, and a decrease in luteinizing hormone levels (p

Access Rights

Not open access