Testosterone Replacement Therapy In Older Male Subjective Memory Complainers: Double-blind Randomized Crossover Placebo-controlled Clinical Trial Of Physiological Assessment And Safety
Document Type
Journal Article
Publisher
Bentham Science Publishers B.V.
Faculty
Faculty of Health, Engineering and Science
School
School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care
RAS ID
20342
Abstract
Testosterone replacement therapy (TRT) has been investigated in older men as a preventative treatment against Alzheimer’s disease and dementia. However, previous studies have been contradictory. We assessed TRT physiological effects in 44 older men (aged 61 ± 7.7 years) with subjective memory complaints using a double blind, randomized, crossover, placebo-controlled study. Participants were randomized into 2 groups, one group received transdermal testosterone (50 mg) daily for 24 weeks, followed by a 4 week wash-out period, then 24 weeks of placebo; the other group received the reverse treatment. Blood evaluation revealed significant increases in total testosterone, free (calculated) testosterone, dihydrotestosterone, and a decrease in luteinizing hormone levels (p
DOI
10.2174/1871527314666150429112112
Access Rights
subscription content
Comments
R Asih, P., J Wahjoepramono, E., Aniwiyanti, V., K Wijaya, L., de Ruyck, K., Taddei, K., ... & Carruthers, M. (2015). Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 14(5), 576-586. Available here