Document Type
Journal Article
Publisher
Royal Society of Chemistry
Faculty
Faculty of Health, Engineering and Science
School
School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care
RAS ID
18810
Abstract
We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer’s disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.
DOI
10.1039/c4mt00060a
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Comments
Rembach, A., Hare, D., Doecke, J., Burnham, S., Volitakis, I., Fowler, C., Cherny, R., McLean, C., Grimm, R., Martins, R. N., Ames, D., Masters, C., Bush, A., & Roberts, B. (2014). Decreased serum zinc is an effect of ageing and not Alzheimer's disease. Metallomics: integrated biometal science, 6(7), 1216-1219. Available here