Abstract
We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer’s disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.
RAS ID
18810
Document Type
Journal Article
Date of Publication
1-1-2014
Faculty
Faculty of Health, Engineering and Science
School
School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Publisher
Royal Society of Chemistry
Recommended Citation
Rembach, A., Hare, D., Doecke, J., Burnham, S., Volitakis, I., Fowler, C., Cherny, R., McLean, C., Grimm, R., Martins, R. N., Ames, D., Masters, C., Bush, A., & Roberts, B. (2014). Decreased Serum Zinc Is An Effect Of Ageing And Not Alzheimer's Disease. DOI: https://doi.org/10.1039/c4mt00060a
Comments
Rembach, A., Hare, D., Doecke, J., Burnham, S., Volitakis, I., Fowler, C., Cherny, R., McLean, C., Grimm, R., Martins, R. N., Ames, D., Masters, C., Bush, A., & Roberts, B. (2014). Decreased serum zinc is an effect of ageing and not Alzheimer's disease. Metallomics: integrated biometal science, 6(7), 1216-1219. Available here