Publication Date
2020
Document Type
Dataset
Publisher
Elsevier
School or Research Centre
School of Medical and Health Sciences
Description
Background: Cardiovascular anomalies are the largest group of congenital anomalies and the major cause of death in young children, with a range of data linking rising atrial septal defect incidence (ASDI) with prenatal cannabis exposure. Objectives / Hypotheses. Is cannabis associated with ASDI in USA? Is this relationship causal?
Methods: Geospatiotemporal cohort study, 1991-2016. Census populations of adults, babies, congenital anomalies, income and ethnicity. Drug exposure data on cigarettes, alcohol abuse, past month cannabis use, analgesia abuse and cocaine taken from National Survey of Drug Use and Health (78.9% response rate). Cannabinoid concentrations from Drug Enforcement Agency. Inverse probability weighted (ipw) regressions. Analysis conducted in R.
Results. ASDI rose nationally three-fold from 27.4 to 82.8 / 10,000 births 1991-2014 during a period when tobacco and alcohol abuse were falling but cannabis was rising. States including Nevada, Kentucky, Mississippi and Tennessee had steeply rising epidemics (Time: Status β-estimate=10.72 (95%C.I. 8.39-13.05), P1.5.
Conclusions. ASDI is associated with cannabis use, frequency, intensity and legalization in a spatiotemporally significant manner, robust to socioeconomicodemographic adjustment and fulfilled causal criteria, consistent with multiple biological mechanisms and similar reports from Hawaii, Colorado, Canada and Australia. Not only are these results of concern in themselves, but they further imply that our list of the congenital teratology of cannabis is as yet incomplete, and highlight the particular cardiovascular toxicology of prenatal cannabinoid and drug exposure.
Additional Information
This dataset was originally published at:
DOI
10.17632/vrnfbytrrr.1
Methodology
Geospatiotemporal cohort study, 1991-2016. Census populations of adults, babies, congenital anomalies, income and ethnicity. Drug exposure data on cigarettes, alcohol abuse, past month cannabis use, analgesia abuse and cocaine taken from National Survey of Drug Use and Health (78.9% response rate). Cannabinoid concentrations from Drug Enforcement Agency. Inverse probability weighted (ipw) regressions. Analysis conducted in R.
Language
Eng
File Format(s)
R, DBF, RDS, GAL, PRJ, SHP, SHX, CSV
File Size
6 MB
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Citation
Reece, A. (2020). Contemporary epidemiology of rising atrial septal defect trends across USA 1991-2016: A combined ecological geotemporospatial and causal inferential study [Dataset]. Elsevier. http://dx.doi.org/10.17632/vrnfbytrrr.1