Author Identifiers

Albert Stuart Reece

https://orcid.org/0000-0002-3256-720X

Collection Type

Dataset

Upload Date

2020

School or Research Centre

School of Medical and Health Sciences

Publisher

Elsevier

Description

Background: Cardiovascular anomalies are the largest group of congenital anomalies and the major cause of death in young children, with a range of data linking rising atrial septal defect incidence (ASDI) with prenatal cannabis exposure. Objectives / Hypotheses. Is cannabis associated with ASDI in USA? Is this relationship causal?

Methods: Geospatiotemporal cohort study, 1991-2016. Census populations of adults, babies, congenital anomalies, income and ethnicity. Drug exposure data on cigarettes, alcohol abuse, past month cannabis use, analgesia abuse and cocaine taken from National Survey of Drug Use and Health (78.9% response rate). Cannabinoid concentrations from Drug Enforcement Agency. Inverse probability weighted (ipw) regressions. Analysis conducted in R.

Results. ASDI rose nationally three-fold from 27.4 to 82.8 / 10,000 births 1991-2014 during a period when tobacco and alcohol abuse were falling but cannabis was rising. States including Nevada, Kentucky, Mississippi and Tennessee had steeply rising epidemics (Time: Status β-estimate=10.72 (95%C.I. 8.39-13.05), P1.5.

Conclusions. ASDI is associated with cannabis use, frequency, intensity and legalization in a spatiotemporally significant manner, robust to socioeconomicodemographic adjustment and fulfilled causal criteria, consistent with multiple biological mechanisms and similar reports from Hawaii, Colorado, Canada and Australia. Not only are these results of concern in themselves, but they further imply that our list of the congenital teratology of cannabis is as yet incomplete, and highlight the particular cardiovascular toxicology of prenatal cannabinoid and drug exposure.

Additional Information

This dataset was originally published at:

https://data.mendeley.com/datasets/vrnfbytrrr/1

Methodology

Geospatiotemporal cohort study, 1991-2016. Census populations of adults, babies, congenital anomalies, income and ethnicity. Drug exposure data on cigarettes, alcohol abuse, past month cannabis use, analgesia abuse and cocaine taken from National Survey of Drug Use and Health (78.9% response rate). Cannabinoid concentrations from Drug Enforcement Agency. Inverse probability weighted (ipw) regressions. Analysis conducted in R.

DOI

10.17632/vrnfbytrrr.1

Language

Eng

File Format(s)

R, DBF, RDS, GAL, PRJ, SHP, SHX, CSV

File Size

6 MB

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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