B-Vitamins Reduce Plasma Levels of beta amyloid

Authors

• Leon Flicker, University of Western Australia
• Ralph Martins, Edith Cowan University
• Jenny Thomas, University of Western Australia
• John Acres, University of Western Australia
• Kevin Taddei, Edith Cowan UniversityFollow
• Samuel Vasikaran, Royal Perth Hospital
• Paul Norman, University of Western Australia
• Konrad Jamrozik, University of Queensland
• Osvaldo Almeida, University of Queensland

Document Type

Journal Article

Keywords

Alzheimer, B vitamins, Amyloid beta protein

Publisher

Elsevier

Faculty

Faculty of Computing, Health and Science

School

School of Exercise, Biomedical and Health Science / Centre of Excellence in Alzheimer’s Disease Research

RAS ID

6016

Comments

Flicker, L., Martins, R. N., Thomas, J., Acres, J., Taddei, K. , Vasikaran, S., Norman, P., Jamrozik, K., & Almeida, O. (2008). B-Vitamins reduce plasma levels of beta amyloid. Neurobiology of Aging, 29(2), 303-305. Available here

Abstract

Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1–40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.