A Multiphasic Role for Pax7 in Tectal Development
Document Type
Journal Article
Keywords
Pax7 - Tectum - Cell proliferation and differentiation - sgfs neurons - Ephrin-A2 - Tectal polarity
Faculty
Faculty of Computing, Health and Science
School
School of Exercise, Biomedical and Health Science
RAS ID
5245
Abstract
The optic tectum differentiates from the mesencephalic alar plate and matures into a characteristically laminated structure. Evidence presented here suggests a role for Pax7 in all stages of development of tectal architecture, from regionalisation to specification of neurons and tectal topography. Analysis of Pax7 expression profiles over a range of developmental stages (E2–E12) suggests a biphasic role for Pax7: initially Pax7 expressing cells in the proliferative neuroepithelial layer establish tectal polarity whereas later Pax7 is expressed in neurons of the retino-recipient precursor stratum griseum et fibrosum superficiale (sgfs) laminae where graded levels may establish tectal topography. Furthermore, co-localisation immunofluorescence confirmed that Pax7 is initially expressed in the majority of proliferative neuroepithelial cells and later in a subset of neurons of the sgfs laminae.
Comments
Thomas, M. , Beazley, L., & Ziman, M. R. (2006). A multiphasic role for Pax7 in tectal development. Experimental Brain Research, 169(2), 266-271. Available here