Neuroimaging Studies of Brain Corpus Striatum Changes among Herion Dependent Patients treated with Herbal Medicine, U' finer TM Capsule

Document Type

Journal Article

Faculty

Faculty of Computing, Health and Science

School

School of Exercise, Biomedical and Health Science

RAS ID

2755

Comments

Jia, S. W., Wang, W., Liu, Y., & Wu, Z. M. (2005). Neuroimaging studies of brain corpus striatum changes among heroin‐dependent patients treated with herbal medicine, U'finer™ capsule. Addiction biology, 10(3), 293-297. Available here

Abstract

Chronic exposure to heroin is associated with structural changes in dopaminergic (DA) neurones. The present study examined the effects of a new herbal medicine, U'finer TM capsule, on the brain corpus striatum and DA systems, comparing pre- and post- treatment in 36 heroin-dependent patients. Neuroimaging studies were performed by using single photon emission computed tomography (SPECT) with 99m Tc-TRODAT-1 as radiotracer. The results show that U'finer TM significantly repaired the damaged bilateral corpus striatum, restoring it to a ‘panda eye? shape, analogous in size and shape to that of the healthy volunteers. DA transporter (DAT) function in the bilateral corpus striatum was restored to a normal state after recovery from neurotoxic insult. These findings suggest that U'finer TM is a reliable herbal medicine in the treatment of heroin dependency.

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