Neurological Soft Signs are Associated with APOE Genotype, Age and Cognitive Performance

Document Type

Journal Article

Keywords

[RSTDPub], Apolipoprotein E, neurological soft signs, memory impairment, apoE promoter polymorphisms, cognitive decline

Publisher

IOS Press

Faculty

Faculty of Computing, Health and Science

School

School of Exercise, Biomedical and Health Science

RAS ID

2757

Comments

Lautenschlager, N., Wu, J. , Laws, S. , Almeida, O., Clarnette, R. , Joesbury, K. , Wagenpfeil, S., Martins, G. , Paton, A. , Gandy, S. , Forstl, H., & Martins, R. N. (2005). Neurological soft signs are associated with APOE genotype, age and cognitive performance. Journal of Alzheimer's Disease, 7(4), 325-330. Available here

Abstract

Neurodegeneration is associated with increased frequency of neurological soft signs (NSS). We designed the present study to investigate the association between NSS and subjective memory complaints, cognitive function and apolipoprotein E genotype in a community-dwelling sample of volunteers participating in an ongoing longitudinal program investigating predictors of cognitive decline. NSS were found to be associated with apolipoprotein E (APOE) ε4 genotype (p = 0.015), age (p = 0.012) and poor cognitive performance, as assessed by the Mini Mental State Examination (p = 0.053). There was no significant difference between subjects with and without memory complaints in relation to the frequency of NSS (p = 0.130). The association with age and the APOE ε4 genotype suggests that the systematic investigation of NSS may contribute to identify subjects at risk of clinically significant cognitive decline in later life.

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Link to publisher version (DOI)

10.3233/JAD-2005-7409