Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals

Authors

• Hamid Sohrabi
• Kristyn Bates, Edith Cowan University
• Mark Rodrigues, Edith Cowan University
• Kevin Taddei, Edith Cowan UniversityFollow
• Simon Laws, Edith Cowan UniversityFollow
• Nicola Lautenschlager
• Satvinder Dhaliwal
• Amy Johnston
• Alan Mackay-Sim
• Samuel Gandy
• Jonathan Foster, Edith Cowan University
• Ralph Martins, Edith Cowan University

Document Type

Journal Article

Keywords

Alzheimer's disease, cognitive decline, depression symptoms, olfactory dysfunction, smell identification, Sniffin' Sticks, subjective memory complaints

Publisher

IOS Press

Faculty

Faculty of Computing, Health and Science

School

School of Exercise, Biomedical and Health Science / Centre of Excellence in Alzheimer’s Disease Research

RAS ID

7633

Comments

Sohrabi, H., Bates, K. A., Rodrigues, M. A., Taddei, K. , Laws, S. , Lautenschlager, N., Dhaliwal, S., Johnston, A., Mackay-Sim, A., Gandy, S., Foster, J. K., & Martins, R. N. (2009). Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's disease, 17(1), 135-42. Available here

Abstract

Olfactory dysfunction has been reported in clinical and preclinical phases of Alzheimer's disease. Subjective memory complaints have been proposed as a potential early indicator for increased risk of Alzheimer's disease, but have also been associated with depression, personality characteristics, and health problems. In this study, we aimed to determine which of these putative markers can predict memory complaints in community-dwelling elderly individuals, focusing on olfactory symptoms. A cohort of 144 elderly volunteers (42 males and 102 females), aged 50 to 86, was recruited from an ongoing longitudinal study. Participants were assessed for olfactory capacities (threshold, discrimination, and identification), subjective memory complaints, depression, and cognitive functions. Subjective memory complaints were significantly associated with olfactory discrimination and identification but not with threshold. Olfactory functions and depressive symptoms were both significantly associated with subjective memory complaints. In addition, memory complainers were significantly worse than non-complainers with respect to olfactory discrimination, identification, and overall olfactory functioning. The findings suggest that olfactory capacity may be a potentially significant biomarker for identifying community-dwelling elderly with memory complaints who are at increased risk for age-related cognitive decline and Alzheimer's disease.