Association study between the D10S1423 microsatellite marker and Alzheimer's disease

Authors

H. Gohlke
T. Illig
N. Klopp
S. Wagenpfeil
L. Konta
S. M. Laws, Edith Cowan UniversityFollow
A. Kurz
M. Riemenschneider

Document Type

Journal Article

Publisher

Elsevier

School

School of Biomedical and Sports Science

Comments

Gohlke, H., Illig, T., Klopp, N., Wagenpfeil, S., Konta, L., Laws, S. M., ... & Riemenschneider, M. (2006). Association study between the D10S1423 microsatellite marker and Alzheimer's disease. Neurobiology of aging, 27(5), pp. 776.e1- 776.e3, https://doi.org/10.1016/j.neurobiolaging.2005.02.016

Abstract

Several studies have reported conflicting results concerning the genetic association between Alzheimer's disease (AD) and the microsatellite marker D10S1423 on chromosome 10p12-14. In an ethnically homogeneous German population of 422 patients with AD and 254 cognitively healthy controls, the 238-bp allele of the D10S1423 marker showed a weak, but after correction for multiple testing no longer significant association with AD (p = 0.015, uncorrected; p = 0.11, corrected). These findings do not support the presence of a relevant susceptibility locus for AD on chromosome 10p12-14.

DOI

10.1016/j.neurobiolaging.2005.02.016