No association of vacuolar protein sorting 26 polymorphisms with alzheimer's disease

Authors

• M. Riemenschneider
• A. Schoepfer-Wendels
• P. Friedrich
• L. Konta
• S. M. Laws, Edith Cowan UniversityFollow
• J. C. Mueller
• A. Kurz
• H. Förstl

Document Type

Journal Article

Keywords

VPS26, Alzheimer's disease, Genetic analysis, Association study

Publisher

Elsevier

School

School of Biomedical and Sports Science

Comments

Riemenschneider, M., Schoepfer-Wendels, A., Friedrich, P., Konta, L., Laws, S. M., Mueller, J. C., ... & Förstl, H. (2007). No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease. Neurobiology of aging, 28(6), 883-884.https://doi.org/10.1016/j.neurobiolaging.2006.05.009

Abstract

Using a case-control sample we evaluated a possible involvement of the Vacuolar protein sorting 26 (VPS26) gene in the pathogenesis of AD. VPS26 located at 10q22.1 denotes a retromer subunit functionally involved in the cellular trafficking of Memapsin 2 (BACE). Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Thus, we conclude that VPS26 can be excluded as a major positional and functional candidate gene conferring risk to AD.