No association of vacuolar protein sorting 26 polymorphisms with alzheimer's disease

Authors

M. Riemenschneider
A. Schoepfer-Wendels
P. Friedrich
L. Konta
S. M. Laws, Edith Cowan UniversityFollow
J. C. Mueller
A. Kurz
H. Förstl

Document Type

Journal Article

Publisher

Elsevier

School

School of Biomedical and Sports Science

Comments

Riemenschneider, M., Schoepfer-Wendels, A., Friedrich, P., Konta, L., Laws, S. M., Mueller, J. C., ... & Förstl, H. (2007). No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease. Neurobiology of aging, 28(6), 883-884.https://doi.org/10.1016/j.neurobiolaging.2006.05.009

Abstract

Using a case-control sample we evaluated a possible involvement of the Vacuolar protein sorting 26 (VPS26) gene in the pathogenesis of AD. VPS26 located at 10q22.1 denotes a retromer subunit functionally involved in the cellular trafficking of Memapsin 2 (BACE). Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Thus, we conclude that VPS26 can be excluded as a major positional and functional candidate gene conferring risk to AD.

DOI

10.1016/j.neurobiolaging.2006.05.009