No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia

Authors

Axel Schumacher
Patricia Friedrich
Janine Diehl-Schmid
Bernd Ibach
Tamara Eisele
Simon M. Laws, Edith Cowan UniversityFollow
Hans Förstl
Alexander Kurz
Matthias Riemenschneider

Document Type

Journal Article

Publisher

Elsevier

School

School of Biomedical and Sports Science

Comments

Schumacher, A., Friedrich, P., Diehl-Schmid, J., Ibach, B., Eisele, T., Laws, S. M., ... & Riemenschneider, M. (2007). No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia. Neurobiology of aging, 28(11), pp. 1789-1790. https://doi.org/10.1016/j.neurobiolaging.2006.07.016

Abstract

Mutations of the chromatin modifying protein 2B gene (CHMP2B) were identified, in a Danish pedigree, to cause familial frontotemporal dementia (FTD). To explore the possible genetic contribution of common CHMP2B variants in sporadic FTD, we analyzed 14 single nucleotide polymorphisms covering the entire genomic region of CHMP2B. After adjustment for multiple testing single marker and haplotype analysis revealed no significant association with sporadic FTD. Thus, we conclude that CHMP2B can be excluded as a susceptibility gene conferring risk to sporadic forms of FTD.

DOI

10.1016/j.neurobiolaging.2006.07.016