Maternal Consumption of Coffee and Tea During Pregnancy and Risk of Childhood ALL: Results from an Australian Case-Control Study
Authors
- Elizabeth Milne, University of Western Australia
- Jill Royle, University of Western Australia
- Lisa C. Bennett, University of Western Australia
- Nicholas H. De Klerk, University of Western Australia
- Helen D. Bailey, University of Western Australia
- Carol Bower, University of Western Australia
- Margaret R. Miller, Edith Cowan UniversityFollow
- John Attia, Universityof Newcastle
- Rodney J. Scott, Universityof Newcastle
- Maria Kirby, Women’s and Children’s Hospital
- Bruce K. Armstrong, Sydney School of Public Health
Document Type
Journal Article
Keywords
Child, Coffee, Diet, Leukemia, Tea
Publisher
Springer
Faculty
Faculty of Computing, Health and Science
School
School of Exercise and Health Sciences / Child Health Promotion Research Centre
RAS ID
12479
Abstract
OBJECTIVES -To investigate whether maternal coffee and/or tea consumption during the last 6 months of pregnancy was associated with risk of childhood ALL. METHODS -Data on coffee and tea drinking during pregnancy from 337 case mothers and 697 control mothers were analyzed using unconditional multivariable logistic regression. A meta-analysis of our findings with those of previous studies was also conducted. RESULTS - There was little evidence of an overall association between maternal coffee consumption and risk of ALL: OR 0.89 (95% CI 0.61, 1.30), although there was some suggestion that higher levels of intake might increase the risk in children of non-smoking mothers: OR for 2+ cups/day = 1.44 (95% CI 0.85, 2.42); this was supported by our meta-analysis. Risk was also elevated among cases with chromosomal translocations. The overall OR for maternal tea consumption was 0.82 (95% CI 0.56, 1.18), although the OR for T-cell ALL was 0.21 (95% CI 0.08, 0.51). Among ALL cases with translocations, the ORs for tea consumption tended to be elevated: OR = 1.70 (95% CI 0.79–3.68) for 2+ cups/day. CONCLUSIONS -The observed increased risk associated with coffee and tea consumption may be confined to ALL with translocations. These associations should be explored further in large international consortia.
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Milne, E., Royle, J., Bennett, L., De Klerk, N., Bailey, H., Bower, C., Miller, M. R., Attia, J., Scott, R., Kirby, M., & Armstrong, B. (2011). Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: Results from an Australian case-control study. Cancer Causes and Control, 22(2), 207-218. Available here