Document Type
Journal Article
Faculty
Faculty of Computing, Health and Science
School
School of Exercise and Health Sciences
RAS ID
12702
Abstract
Purpose. To examine the effects of two doses of low-frequency (12 Hz), low-magnitude (0.3 g), whole body vibration on markers of bone formation and resorption in postmenopausal women. Methods. Women were recruited and randomized into a sham vibration control group, one time per week vibration group (1×/week), or three times per week vibration group (3×/week). Vibration exposure consisted of 20 minutes of intermittent vibration for the 1×/week and 3×/week groups, and sham vibration (<0.1 g) for the control group for eight weeks. Double-blinded primary outcome measures were urine markers of bone resorption: N-telopeptide X normalised to creatinine (NTx/Cr) and bone formation: bone-specific alkaline phosphatase (ALP). Results. Forty-six women (59.8 ± 6.2 years, median 7.3 years since menopause) were enrolled. NTx/Cr was significantly reduced (34.6%) in the 3×/wk vibration group but not in the 1×/wk vibration group compared with sham control (P<.01) group. No effect of time or group allocation was observed on the bone formation marker ALP (P=.27). Conclusion. We have shown for the first time that low-frequency, low-magnitude vibration 3×/week for eight weeks in postmenopausal women results in a significant reduction in NTx/Cr, a marker of bone resorption, when compared with sham vibration exposure.
DOI
10.4061/2011/710387
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Comments
Turner, S., Torode, M., Climstein, M., Naughton, G., Greene, D., Baker, M. , & Fiatarone Singh, M. (2011). A Randomized Controlled Trial of Whole Body Vibration Exposure on Markers of Bone Turn-over in Postmenopausal Women. Journal of Osteoporosis, 2011(1), 10. Available here