AST-induced Bone Loss in Men with Prostate Cancer: Exercise as a Potential Countermeasure
Document Type
Journal Article
Keywords
androgen suppression, bone density, fracture risk, physical exerciseandrogen, antiandrogen, bisphosphonic acid derivative, estrogen, gonadorelin agonist, testosterone, androgen deprivation therapy, bone density, bone metabolism, bone strength, breast disease, breast swelling, breast tenderness, cancer adjuvant therapy, cancer survival, castration, exercise, exercise intensity, fracture, ground reaction force, human, jumping, orchiectomy, osteolysis, osteopenia, osteoporosis, priority journal, prostate cancer, quality of life, resistance training, review, risk factor, sedentary lifestyle, walking speed, weight bearing, Androgen Antagonists, Androgens, Bone Diseases, Metabolic, Exercise Therapy, Humans, Male, Osteoporosis, Prostatic Neoplasms
Faculty
Faculty of Computing, Health and Science
School
ECU Health and Wellness Institute / Centre for Exercise and Sports Science Research
RAS ID
14892
Abstract
Androgen suppression treatment (AST) for men with prostate cancer is associated with a number of treatment-related side effects including an accelerated rate of bone loss. This loss of bone is greatest within the first year of AST and increases the risk for fracture. Pharmaceutical treatment in the form of bisphosphonates is currently used to counter the effects of hormone suppression on bone but is costly and associated with potential adverse effects. Recently, exercise has been shown to be an important adjuvant therapy to manage a range of treatment-related toxicities and enhance aspects of quality of life for men receiving AST. We propose that physical exercise may also have an important role in not only attenuating the bone loss associated with AST but in improving bone health and reducing fracture risk. In this review, the rationale underlying exercise as a countermeasure to AST-induced bone loss is provided.
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Comments
Bolam, K., Galvao, D. A., Spry, N. A., Newton, R. , & Taaffe, D. (2012). AST-induced Bone Loss in Men with Prostate Cancer: Exercise as a Potential Countermeasure. Prostate Cancer and Prostatic Diseases, 15(4), 329-338. Available here