Document Type

Journal Article

Publication Title

BMJ Open

Volume

12

Issue

7

PubMed ID

35868824

Publisher

BMJ Publishing Group

School

Centre for Precision Health

RAS ID

51819

Funders

National Natural Science Foundation of China (No. 82073659) / Provincial Science and Technology Special Fund of Guangdong in 2021 (No. 2021123071-1)

Comments

Tian, C., Mahara, G., Zhang, H., & Tan, X. (2022). Association of immunoglobulin G N-glycosylation with carotid atherosclerotic plaque phenotypes and actual clinical cardiovascular events: A study protocol for a longitudinal prospective cohort study. BMJ Open, 12, 1-6, e058922. https://doi.org/10.1136/bmjopen-2021-058922

Abstract

Introduction Immune-inflammatory response plays a key role in the pathogenesis of atherosclerosis. IgG N-glycosylation is reported to be associated with the 10-year atherosclerotic cardiovascular disease risk score and subclinical atherosclerosis. However, the relationship of IgG glycosylation with actual clinical cardiovascular disease (CVD) events and plaque phenotypes has rarely been investigated. Therefore, this study aims to understand whether IgG glycosylation traits are correlated with actual clinical CVD events and plaque phenotypes. Methods and analysis Designed to verify the efficacy of IgG glycosylation as a risk for CVD events and screen potential biomarkers of CVD to prevent atherosclerosis occurrence, this longitudinal prospective cohort study will be conducted at the First Affiliated Hospital of Shantou University Medical College, China. In total, 2720 participants routinely examined by carotid ultrasound will be divided into different groups according to plaque phenotype characteristics. Ultra-performance liquid chromatography will be performed to separate and detect IgG N-glycans in serum collected at baseline and at the end of the first, second and third years. The primary outcome is the actual clinical CVD composite events, including non-fatal myocardial infarction, death due to coronary heart disease, and fatal or non-fatal stroke. Ethics and dissemination The Clinical Ethics Committee of the First Affiliated Hospital of Shantou University Medical College approved this study (number: B-2021-127). Findings of this study will be submitted for publication in peer-reviewed journals. Trial registration number ChiCTR2100048740.

DOI

10.1136/bmjopen-2021-058922

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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