Abstract
Objectives: We assessed the effect of feeding preterm or low birth weight infants with infant formula compared with mother's own milk on mortality, morbidity, growth, neurodevelopment, and disability. Methods: We searched Medline (Ovid), Embase (Ovid), and Cochrane Central Register of Controlled Studies to October 1, 2021. Results: Forty-two studies enrolling 89 638 infants fulfilled the inclusion criteria. We did not find evidence of an effect on mortality (odds ratio [OR] 1.26, 95% confidence interval [CI] 0.91-1.76), infection (OR 1.52, 95% CI 0.98-2.37), cognitive neurodevelopment (standardized mean difference -1.30, 95% CI -3.53 to 0.93), or on growth parameters. Formula milk feeding increased the risk of necrotizing enterocolitis (OR 2.99, 95% CI 1.75-5.11). The Grading of Recommendations Assessment, Development, and Evaluation certainty of evidence was low for mortality and necrotizing enterocolitis, and very low for neurodevelopment and growth outcomes. Conclusions: In preterm and low birth weight infants, low to very low-certainty evidence indicates that feeding with infant formula compared with mother's own milk has little effect on all-cause mortality, infection, growth, or neurodevelopment, and a higher risk of developing necrotizing enterocolitis.
RAS ID
52126
Document Type
Journal Article
Date of Publication
1-1-2022
Volume
150
Funding Information
Edith Cowan University received funding from the World Health Organization (WHO)
PubMed ID
35921674
School
Kurongkurl Katitjin
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Publisher
American Academy of Pediatrics
Recommended Citation
Strobel, N. A., Adams, C., McAullay, D. R., & Edmond, K. M. (2022). Mother's own milk compared with formula milk for feeding preterm or low birth weight infants: Systematic review and meta-analysis. DOI: https://doi.org/10.1542/peds.2022-057092D
Comments
Strobel, N. A., Adams, C., McAullay, D. R., & Edmond, K. M. (2022). Mother's own milk compared with formula milk for feeding preterm or low birth weight infants: Systematic review and meta-analysis, 150 (Supplement 1), e2022057092D. https://doi.org/10.1542/peds.2022-057092D