Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy
Abstract
Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and > 14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022;92:358–363.
RAS ID
52193
Document Type
Journal Article
Date of Publication
1-1-2022
Volume
92
Issue
3
Funding Information
National Institute on Aging. Grant Numbers: UF1AG032438; K23AG049087; P01AG036694, P01AG036694, K23AG049087, UF1AG032438
National Institute of Health. Grant Numbers: S10RR023043, S10RR023401, S10RR021110
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering
Massachusetts General Hospital
Center for Biomedical Imaging
National Health and Medical Research Council
Alzheimer's Society of Canada
National Institute of Neurologic Diseases and Stroke. Grant Number: R01NS070834
PubMed ID
35670654
School
Centre of Excellence for Alzheimer's Disease Research and Care / School of Medical and Health Sciences
Grant Number
NHMRC Number : APP1129627
Copyright
subscription content
Publisher
Wiley
Recommended Citation
Shirzadi, Z., Yau, W. W., Schultz, S. A., Schultz, A. P., Scott, M. R., Goubran, M., Mojiri-Forooshani, P., Joseph-Mathurin, N., Kantarci, K., Preboske, G., Wermer, M. J., Jack, C., Benzinger, T., Taddei, K., Sohrabi, H. R., Sperling, R. A., Johnson, K. A., Bateman, R. J., Martins, R. N., Greenberg, S. M., Chhatwal, J. P., & (2022). Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy. DOI: https://doi.org/10.1002/ana.26429
Comments
Shirzadi, Z., Yau, W. Y. W., Schultz, S. A., Schultz, A. P., Scott, M. R., Goubran, M., ... & DIAN Investigators. (2022). Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy. Annals of Neurology, 92(3), 358-363.
https://doi.org/10.1002/ana.26429