Title

Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy

Document Type

Journal Article

Publication Title

Annals of Neurology

Volume

92

Issue

3

First Page

358

Last Page

363

PubMed ID

35670654

Publisher

Wiley

School

Centre of Excellence for Alzheimer's Disease Research and Care / School of Medical and Health Sciences

RAS ID

52193

Funders

National Institute on Aging. Grant Numbers: UF1AG032438; K23AG049087; P01AG036694, P01AG036694, K23AG049087, UF1AG032438

National Institute of Health. Grant Numbers: S10RR023043, S10RR023401, S10RR021110

National Institutes of Health (NIH)

National Institute of Biomedical Imaging and Bioengineering

Massachusetts General Hospital

Center for Biomedical Imaging

National Health and Medical Research Council

Alzheimer's Society of Canada

National Institute of Neurologic Diseases and Stroke. Grant Number: R01NS070834

Grant Number

NHMRC Number : APP1129627

Comments

Shirzadi, Z., Yau, W. Y. W., Schultz, S. A., Schultz, A. P., Scott, M. R., Goubran, M., ... & DIAN Investigators. Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy. Annals of Neurology, 92(3), 358-363.

https://doi.org/10.1002/ana.26429

Abstract

Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and > 14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022;92:358–363.

DOI

10.1002/ana.26429

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