Obesity and prostate cancer: A narrative review

Document Type

Journal Article

Publication Title

Critical Reviews in Oncology/Hematology

Volume

169

Publisher

Elsevier

School

School of Medical and Health Sciences

RAS ID

40501

Funders

Australian Government Research Training Programme postgraduate scholarship

Vice-Chancellor Professorial Research Fellowship

Cancer Council Western Australia Postdoctoral Research Fellowship

Comments

Wilson, R. L., Taaffe, D. R., Newton, R. U., Hart, N. H., Lyons-Wall, P., & Galvão, D. A. (2022). Obesity and prostate cancer: a narrative review. Critical reviews in Oncology/Hematology, 169, 103543.

https://doi.org/10.1016/j.critrevonc.2021.103543

Abstract

Overweight and obese men with prostate cancer are at an increased risk of disease recurrence, exacerbated treatment-related adverse effects, development of obesity-related comorbidities, earlier progression and development of metastatic disease, and higher all-cause and prostate cancer-specific mortality. The physiological mechanisms associating obesity with poor prostate cancer outcomes remain largely unknown; however, an increased inflammatory environment and metabolic irregularities associated with excess fat mass are commonly postulated. Although research is limited, fat loss strategies using exercise and nutrition programmes may slow down prostate cancer progression and improve a patient's prognosis. This review is an overview of: 1) the association between obesity and poor prostate cancer prognosis; 2) potential physiological mechanisms linking obesity and prostate cancer progression; 3) the effect of obesity on treatments for prostate cancer; and 4) the potential for weight loss strategies to improve outcomes in patients with prostate cancer.

DOI

10.1016/j.critrevonc.2021.103543

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