Title

The voices of stakeholders nvolved in precision medicine: The co-design and evaluation of qualitative indicators of intervention acceptability, fidelity and context in PRecISion medicine for children with cancer in Australia

Document Type

Journal Article

Publication Title

Qualitative Health Research

Publisher

Sage

School

School of Nursing and Midwifery

RAS ID

45449

Funders

Luminesce Alliance – Innovation for Children’s Health

National Health and Medical Research Council

Grant Number

NHMRC Numbers : APP1176620, APP1135048, APP9100002

Comments

Smith, J., Braithwaite, J., O’Brien, T. A., Smith, S., Tyrrell, V. J., Mould, E. V., ... & Rapport, F. (2022). The voices of stakeholders nvolved in precision medicine: The co-design and evaluation of qualitative indicators of intervention acceptability, fidelity and context in PRecISion medicine for children with cancer in Australia. Qualitative Health Research, 32(12), 1865-1880.

https://doi.org/10.1177/10497323221120501

Abstract

We report a novel approach of amalgamating implementation outcomes of acceptability and fidelity alongside context as a new way of qualitatively evaluating implementation outcomes and context of a precision medicine intervention. A rapid qualitative online proforma was co-designed with stakeholders and sent to a purposive sample of healthcare professionals involved in an early-phase clinical trial intervention. Data were analysed using Framework Analysis. A total of 24 out of 68 proformas were returned. Although some participants raised concerns about drug medication access issues, the main intervention was well accepted and understood across professional groups. Comprehension was enhanced through exposure to specialist multidisciplinary meeting arrangements. In conclusion, a rapid data collection tool and framework are now available to assess readily measurable, qualitative indicators of acceptability, fidelity of receipt and contextual fit within the dynamic precision medicine context.

DOI

10.1177/10497323221120501

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