Document Type
Journal Article
Publication Title
Journal of Infection and Public Health
Volume
15
Issue
2
First Page
277
Last Page
288
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
52058
Funders
Khalifa University-Covid and Pandemic Research Award (CPRA)Reference number 2020-004
Abstract
The heterogeneous phenotypes among patients with coronavirus disease 2019 (COVID-19) has drawn worldwide attention, especially those with severe symptoms without comorbid conditions. Immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative virus of COVID-19, occur mainly by the innate immune response via the interferon (IFN)-mediated pathways, and the adaptive immunity via the T lymphocyte and the antibody mediated pathways. The ability of the original Wuhan SARS-CoV-2 strain, and possibly more so with new emerging variants, to antagonize IFN-mediated antiviral responses can be behind the higher early viral load, higher transmissibility, and milder symptoms compared to SARS-CoV and are part of the continued clinical evolution of COVID-19. Since it first emerged, several variants of SARS-CoV-2 have been circulating worldwide. Variants that have the potential to elude natural or vaccine-mediated immunity are variants of concern. This review focuses on the main host factors that may explain the immune responses to SARS-CoV-2 and its variants in the context of susceptibility, severity, and preexisting immunity.
DOI
10.1016/j.jiph.2022.01.007
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Alefishat, E., Jelinek, H. F., Mousa, M., Tay, G. K., & Alsafar, H. S. (2022). Immune response to SARS-CoV-2 Variants: A focus on severity, susceptibility, and preexisting immunity. Journal of Infection and Public Health, 15, 277-288.
https://doi.org/10.1016/j.jiph.2022.01.007