Abstract

Background:

This systematic review and meta-analysis synthesized evidence in patients with ovarian cancer at diagnosis and/or during first-line treatment on; (i) the association of body weight, body composition, diet, exercise, sedentary behavior, or physical fitness with clinical outcomes; and (ii) the effect of exercise and/or dietary interventions.

Methods:

Risk of bias assessments and best-evidence syntheses were completed. Meta-analyses were performed when ≥ 3 papers presented point estimates and variability measures of associations or effects.

Results:

Body mass index (BMI) at diagnosis was not significantly associated with survival. Although the following trends were not supported by the best-evidence syntheses, the meta-analyses revealed that a higher BMI was associated with a higher risk of post-surgical complications (n = 5, HR: 1.63, 95 % CI: 1.06 – 2.51, p = 0.030), a higher muscle mass was associated with a better progression-free survival (n = 3, HR: 1.41, 95 % CI: 1.04 – 1.91, p = 0.030) and a higher muscle density was associated with a better overall survival (n = 3, HR: 2.12, 95 % CI: 1.62 – 2.79, p < 0.001). Muscle measures were not significantly associated with surgical or chemotherapy-related outcomes.

Conclusions:

The prognostic value of baseline BMI for clinical outcomes is limited, but muscle mass and density may have more prognostic potential. High-quality studies with comprehensive reporting of results are required to improve our understanding of the prognostic value of body composition measures for clinical outcomes.

Systematic review registration number:

PROSPERO identifier CRD42020163058.

RAS ID

52357

Document Type

Journal Article

Date of Publication

1-1-2022

Volume

14

Issue

19

School

Exercise Medicine Research Institute

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Publisher

MDPI

Comments

Stelten, S., Schofield, C., Hartman, Y. A., Lopez, P., Kenter, G. G., Newton, R. U., ... & Buffart, L. M. (2022).Association between energy balance-related factors and clinical outcomes in patients with ovarian cancer: A systematic review and meta-analysis. Cancers, 14(19), Article 4567. https://doi.org/10.3390/cancers14194567

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Link to publisher version (DOI)

10.3390/cancers14194567