Association between energy balance-related factors and clinical outcomes in patients with ovarian cancer: A systematic review and meta-analysis

Authors

Stephanie Stelten
Christelle Schofield, Edith Cowan UniversityFollow
Yvonne A. W. Hartman
Pedro Lopez, Edith Cowan UniversityFollow
Gemma G. Kenter
Robert U. Newton, Edith Cowan UniversityFollow
Daniel A. Galvão, Edith Cowan UniversityFollow
Meeke Hoedjes
Dennis R. Taaffe, Edith Cowan UniversityFollow
Luc R. C. W. van Lonkhuijzen
Carolyn McIntyre, Edith Cowan UniversityFollow
Laurien M. Buffart, Edith Cowan UniversityFollow

Document Type

Journal Article

Publication Title

Cancers

Volume

14

Issue

19

Publisher

MDPI

School

Exercise Medicine Research Institute

RAS ID

52357

Comments

Stelten, S., Schofield, C., Hartman, Y. A., Lopez, P., Kenter, G. G., Newton, R. U., ... & Buffart, L. M. (2022).Association between energy balance-related factors and clinical outcomes in patients with ovarian cancer: A systematic review and meta-analysis. Cancers, 14(19), Article 4567. https://doi.org/10.3390/cancers14194567

Abstract

Background:

This systematic review and meta-analysis synthesized evidence in patients with ovarian cancer at diagnosis and/or during first-line treatment on; (i) the association of body weight, body composition, diet, exercise, sedentary behavior, or physical fitness with clinical outcomes; and (ii) the effect of exercise and/or dietary interventions.

Methods:

Risk of bias assessments and best-evidence syntheses were completed. Meta-analyses were performed when ≥ 3 papers presented point estimates and variability measures of associations or effects.

Results:

Body mass index (BMI) at diagnosis was not significantly associated with survival. Although the following trends were not supported by the best-evidence syntheses, the meta-analyses revealed that a higher BMI was associated with a higher risk of post-surgical complications (n = 5, HR: 1.63, 95 % CI: 1.06 – 2.51, p = 0.030), a higher muscle mass was associated with a better progression-free survival (n = 3, HR: 1.41, 95 % CI: 1.04 – 1.91, p = 0.030) and a higher muscle density was associated with a better overall survival (n = 3, HR: 2.12, 95 % CI: 1.62 – 2.79, p < 0.001). Muscle measures were not significantly associated with surgical or chemotherapy-related outcomes.

Conclusions:

The prognostic value of baseline BMI for clinical outcomes is limited, but muscle mass and density may have more prognostic potential. High-quality studies with comprehensive reporting of results are required to improve our understanding of the prognostic value of body composition measures for clinical outcomes.

Systematic review registration number:

PROSPERO identifier CRD42020163058.

DOI

10.3390/cancers14194567

Related Publications

Schofield, C. (2022). Muscle morphology and function in women with advanced-stage ovarian cancer: Relevance in care and response to exercise medicine. https://ro.ecu.edu.au/theses/2601

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