Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease
Document Type
Journal Article
Publication Title
Alzheimer's and Dementia
Volume
18
Issue
10
First Page
1754
Last Page
1764
Publisher
Wiley
School
School of Medical and Health Sciences
RAS ID
42660
Funders
National Institute on Aging (NIA)
German Center for Neurodegenerative Diseases (DZNE)
Raul Carrea Institute for Neurological Research (FLENI)
Japan Agency for Medical Research and Development, AMED
NIHR UCL/UCLH Biomedical Research Centre
MRC Dementias Platform UK (MR/L023784/1 and MR/009076/1)
Abstract
As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and “sporadic” late-onset AD (LOAD) is critical to determine generalizability of findings between these cohorts. Cognitive trajectories of ADAD mutation carriers (MCs) and autopsy-confirmed LOAD individuals were compared to address this question. Longitudinal rates of change on cognitive measures were compared in ADAD MCs (n = 310) and autopsy-confirmed LOAD participants (n = 163) before and after symptom onset (estimated/observed). LOAD participants declined more rapidly in the presymptomatic (preclinical) period and performed more poorly at symptom onset than ADAD participants on a cognitive composite. After symptom onset, however, the younger ADAD MCs declined more rapidly. The similar but not identical cognitive trajectories (declining but at different rates) for ADAD and LOAD suggest common AD pathologies but with some differences.
DOI
10.1002/alz.12505
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Comments
Buckles, V. D., Xiong, C., Bateman, R. J., Hassenstab, J., Allegri, R., Berman, S. B., ... & Dominantly Inherited Alzheimer's Network. (2022). Different rates of cognitive decline in autosomal dominant and late‐onset Alzheimer disease. Alzheimer's & Dementia, 18(10), 1754-1764. https://doi.org/10.1002/alz.12505