Decoding the mechanism of hypertension through multiomics profiling

Authors

Eric Adua, Edith Cowan UniversityFollow

Document Type

Journal Article

Publication Title

Journal of Human Hypertension

Publisher

Nature

School

School of Medical and Health Sciences

RAS ID

54213

Comments

Adua, E. (2023). Decoding the mechanism of hypertension through multiomics profiling. Journal of Human Hypertension, 37, 253-264.

https://doi.org/10.1038/s41371-022-00769-8

Abstract

Hypertension, characterised by a constant high blood pressure, is the primary risk factor for multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations in high-throughput technologies have enabled the global exploration of the whole genome (genomics), revealing dysregulated genes that are linked to hypertension. Moreover, post-genomic biomarkers, from the emerging fields of transcriptomics, proteomics, glycomics and lipidomics, have provided new insights into the molecular underpinnings of hypertension. In this paper, we review the pathophysiology of hypertension, and highlight the multi-omics approaches for hypertension prediction and diagnosis.

DOI

10.1038/s41371-022-00769-8

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.