Can exercise increase natural killer cell infiltration of the prostate?

Authors/Creators

Daniel A. Galvão, Edith Cowan UniversityFollow
Dennis R. Taaffe, Edith Cowan UniversityFollow
Jin Soo Kim, Edith Cowan UniversityFollow
Robert U. Newton, Edith Cowan UniversityFollow
Alejandro Lucia

Abstract

Regular exercise is a well-established intervention to reduce prostate cancer treatment toxicities. In addition, higher levels of physical activity are associated with longer prostate cancer survival. However, the mechanisms underlying the protective effect of exercise against tumour development/progression remain to be clearly elucidated. In this context, Djurhuus et al. have reported on the first human study examining the effects of an exercise intervention on natural killer (NK) cell infiltration in localised prostate cancer. This is an important question: NK cells are constantly on high alert for malignant cell transformation, monitoring target cells for surface expression of NK cell-activating receptors, and are able to destroy proliferating tumour cells, with high tumour infiltration of these cells therefore considered a positive prognostic factor in a variety of malignancies, including metastatic disease.

RAS ID

53100

Document Type

Editorial

Date of Publication

1-1-2023

Volume

131

Issue

1

PubMed ID

36546724

School

Exercise Medicine Research Institute / School of Medical and Health Sciences

Copyright

free_to_read

Publisher

Wiley

Comments

Galvão, D. A., Taaffe, D. R., Kim, J. S., Newton, R. U., & Lucia, A. (2023). Can exercise increase natural killer cell infiltration of the prostate?. BJU international, 131(1), 1-3. https://doi.org/10.1111/bju.15904

Recommended Citation

Galvão, D. A., Taaffe, D. R., Kim, J. S., Newton, R. U., & Lucia, A. (2023). Can exercise increase natural killer cell infiltration of the prostate?. DOI: https://doi.org/10.1111/bju.15904