Can exercise increase natural killer cell infiltration of the prostate?

Abstract

Regular exercise is a well-established intervention to reduce prostate cancer treatment toxicities. In addition, higher levels of physical activity are associated with longer prostate cancer survival. However, the mechanisms underlying the protective effect of exercise against tumour development/progression remain to be clearly elucidated. In this context, Djurhuus et al. have reported on the first human study examining the effects of an exercise intervention on natural killer (NK) cell infiltration in localised prostate cancer. This is an important question: NK cells are constantly on high alert for malignant cell transformation, monitoring target cells for surface expression of NK cell-activating receptors, and are able to destroy proliferating tumour cells, with high tumour infiltration of these cells therefore considered a positive prognostic factor in a variety of malignancies, including metastatic disease.

Document Type

Editorial

Date of Publication

1-1-2023

Volume

131

Issue

1

PubMed ID

36546724

Publication Title

BJU International

Publisher

Wiley

School

Exercise Medicine Research Institute / School of Medical and Health Sciences

RAS ID

53100

Comments

Galvão, D. A., Taaffe, D. R., Kim, J. S., Newton, R. U., & Lucia, A. (2023). Can exercise increase natural killer cell infiltration of the prostate?. BJU international, 131(1), 1-3. https://doi.org/10.1111/bju.15904

Copyright

free_to_read

First Page

1

Last Page

3

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Link to publisher version (DOI)

10.1111/bju.15904