Document Type
Journal Article
Publication Title
Environmental Research
Volume
216
PubMed ID
36347395
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
56596
Funders
Program of the Natural Science Foundation of China College Students Scientific Training Plan Project of Beijing Colleges Universities High-level Talents Cross-Cultivation
Abstract
Background: Extensive studies have linked PM2.5 and PM10 with respiratory diseases (RD). However, few is known about causal association between PM1 and morbidity of RD. We aimed to assess the causal effects of PM1 on cause-specific RD. Methods: Hospital admission data were obtained for RD during 2014 and 2019 in Beijing, China. Negative control exposure and extreme gradient boosting with SHapley Additive exPlanation was used to explore the causality and contribution between PM1 and RD. Stratified analysis by gender, age, and season was conducted. Results: A total of 1,183,591 admissions for RD were recorded. Per interquartile range (28 μg/m3) uptick in concentration of PM1 corresponded to a 3.08% [95% confidence interval (CI): 1.66%–4.52%] increment in morbidity of total RD. And that was 4.47% (95% CI: 2.46%–6.52%) and 0.15% (95% CI: 1.44%-1.78%), for COPD and asthma, respectively. Significantly positive causal associations were observed for PM1 with total RD and COPD. Females and the elderly had higher effects on total RD, COPD, and asthma only in the warm months (Z = 3.03, P = 0.002; Z = 4.01, P < 0.001; Z = 3.92, P < 0.001; Z = 2.11, P = 0.035; Z = 2.44, P = 0.015). Contribution of PM1 ranked first, second and second for total RD, COPD, and asthma among air pollutants. Conclusion: PM1 was causally associated with increased morbidity of total RD and COPD, but not causally associated with asthma. Females and the elderly were more vulnerable to PM1-associated effects on RD.
DOI
10.1016/j.envres.2022.114746
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Lv, S., Liu, X., Li, Z., Lu, F., Guo, M., Liu, M., . . . Guo, X. (2023). Causal effect of PM1 on morbidity of cause-specific respiratory diseases based on a negative control exposure. Environmental Research, 216(Part 4), article 114746. https://doi.org/10.1016/j.envres.2022.114746