Asthma and allergies in a cohort of adolescents conceived with ART
Document Type
Journal Article
Publication Title
Reproductive BioMedicine Online
Volume
45
Issue
6
First Page
1255
Last Page
1265
PubMed ID
36182641
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
51823
Funders
National Health and Medical Research Council
Grant Number
NHMRC Numbers : 1042269, 211912, 3209, 403981
Grant Link
http://purl.org/au-research/grants/nhmrc/1042269 http://purl.org/au-research/grants/nhmrc/211912 http://purl.org/au-research/grants/nhmrc/3209
Abstract
Research question: Are asthma and allergies more common in adolescents conceived with assisted reproductive technologies (ART) compared with adolescents conceived without? Design: The Growing Up Healthy Study (GUHS) is a prospective cohort study including ART-conceived offspring born between 1991 and 2001 in Perth, Australia. Their long-term health outcomes, including asthma and allergy parameters, were compared with those of their counterparts conceived without ART from the Raine Study Generation 2 (Gen2), born in 1989–1991. At age 14, 152 GUHS and 1845 Gen2 participants completed the following assessments: the International Studies of Asthma and Allergies in Childhood (ISAAC) questionnaire, spirometry, methacholine challenge testing and skin prick testing (SPT). Results: No differences were detected in the prevalence of current asthma (7.7 % versus 10.8 %, adjusted odds ratio [aOR] 0.82 (95 % CI 0.44 – 1.52), P = 0.530). Spirometry-measured lung volumes were larger in the ART adolescents. Bronchial hyperresponsiveness was less prevalent in the ART cohort (8.8 versus 18.6 %, P = 0.006). Current allergic rhinoconjunctivitis (ARC) rates were significantly higher in the ART cohort (32.4 % versus 25.2 %, aOR 1.52 [95 % CI 1.03 – 2.26], P = 0.036), with no cohort differences in atopic dermatitis. Food allergies were more prevalent in the ART cohort (20.7 versus 10.9 %, aOR 1.89 [95 % CI 1.17 – 3.06], P = 0.010) with more adolescents having a positive SPT (68.0 % versus 45.4 %, aOR 3.03 [95 % 1.99 – 4.63], P < 0.001). Conclusions: This study reports no differences in asthma prevalence, slightly altered lung function, an increase in ARC, food allergies and positive SPT in the ART-conceived adolescents. These findings are important to families and healthcare providers and may open up possibilities for targeted screening and treatment. Further studies are required to confirm these findings.
DOI
10.1016/j.rbmo.2022.07.007
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Comments
Wijs, L. A., Doherty, D. A., Keelan, J. A., Penova-Veselinovic, B., Burton, P., Yovich, J. L., ... & Hart, R. J. (2022). Asthma and allergies in a cohort of adolescents conceived with ART. Reproductive BioMedicine Online, 45(6), 1255-1265. https://doi.org/10.1016/j.rbmo.2022.07.007