Abstract

Background: In recent years, a potential beneficial role of Vitamin K in neuromuscular function has been recognised. However, the optimal dietary intake of Vitamin K to support muscle function in the context of falls prevention remains unknown. Objective: To examine the relationship of dietary Vitamin K1 and K2 with muscle function and long-term injurious fall-related hospitalisations in older women. Design: Cohort study. Participants: 1347 community-dwelling older Australian women ≥ 70 years. Measurements: A new Australian Vitamin K nutrient database, supplemented with published data, was used to calculate Vitamin K1 and K2 intake from a validated food frequency questionnaire at baseline (1998). Muscle function (grip strength and timed-up-and-go; TUG) as well plasma Vitamin D status (25OHD) were also assessed at baseline. Fall-related hospitalisations over 14.5 years were obtained from linked health records. Multivariable-adjusted logistic regression and Cox-proportional hazard models were used to analyse the data. Results: Over 14.5 years of follow-up (14,774 person-years), 535 (39.7 %) women experienced a fall-related hospitalisation. Compared to women with the lowest Vitamin K1 intake (Quartile 1, median 49 µg/d), those with the highest intake (Quartile 4, median 120 µg/d) had 29 % lower odds (OR 0.71 95 % CI 0.52 – 0.97) for slow TUG performance ( > 10.2 s), and 26 % lower relative hazards of a fall-related hospitalisation (HR 0.74 95 %CI 0.59 – 0.93) after multivariable adjustment. These associations were non-linear and plateaued at moderate intakes of ∼ 70 – 100 µg/d. There was no relation to grip strength. Vitamin K2 intakes were not associated with muscle function or falls. Conclusion: A higher habitual Vitamin K1 intake was associated with better physical function and lower long-term injurious falls risk in community-dwelling older women. In the context of musculoskeletal health, Vitamin K1 found abundantly in green leafy vegetables should be promoted.

Keywords

injury, menaquinone, muscle function, nutrition, Phylloquinone

Document Type

Journal Article

Date of Publication

1-10-2023

Volume

27

Issue

1

PubMed ID

36651485

Publication Title

Journal of Nutrition, Health and Aging

Publisher

Springer

School

Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences

RAS ID

47197

Funders

National Health and Medical Research Council / Healthway / Western Australian Health Promotion Foundation / Department of Health, Western Australia / Merit Award / Royal Perth Hospital Career Advancement Fellowship (CAF 130/2020) / Emerging Leader Fellowship, Western Australian Future Health and Innovation Fund / Department of Health (WA) / National Heart Foundation of Australia Post-Doctoral Research Fellowship (ID: 102498) / National Heart Foundation of Australia Future Leader Fellowship (ID: 102817)

Grant Number

NHMRC Numbers : 254627, 303169, 572604, 1172987, 1116973

Grant Link

http://purl.org/au-research/grants/nhmrc/1116973 / http://purl.org/au-research/grants/nhmrc/572604 / http://purl.org/au-research/grants/nhmrc/303169 / http://purl.org/au-research/grants/nhmrc/254627

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Comments

Sim, M., Smith, C., Bondonno, N. P., Radavelli-Bagatini, S., Blekkenhorst, L. C., Dalla Via, J., ... & Lewis, J. R. (2023). Higher dietary vitamin K intake is associated with better physical function and lower long-term injurious falls risk in community-dwelling older women. The Journal of Nutrition, Health & Aging, 27, 38-45. https://doi.org/10.1007/s12603-022-1866-9

First Page

38

Last Page

45

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Link to publisher version (DOI)

10.1007/s12603-022-1866-9