Document Type
Journal Article
Publication Title
Cancers
Volume
15
Issue
5
Publisher
MDPI
School
School of Medical and Health Sciences / Exercise Medicine Research Institute
RAS ID
55055
Funders
National Health and Medical Research Council Centre of Research Excellence (CRE) in Prostate Cancer Survivorship Scholarship (PL)
Abstract
To investigate the association between skeletal muscle mass and adiposity measures with disease-free progression (DFS) and overall survival (OS) in patients with advanced lung cancer receiving immunotherapy, we retrospectively analysed 97 patients (age: 67.5 ± 10.2 years) with lung cancer who were treated with immunotherapy between March 2014 and June 2019. From computed tomography scans, we assessed the radiological measures of skeletal muscle mass, and intramuscular, subcutaneous and visceral adipose tissue at the third lumbar vertebra. Patients were divided into two groups based on specific or median values at baseline and changes throughout treatment. A total number of 96 patients (99.0 %) had disease progression (median of 11.3 months) and died (median of 15.4 months) during follow-up. Increases of 10 % in intramuscular adipose tissue were significantly associated with DFS (HR: 0.60, 95 % CI: 0.38 to 0.95) and OS (HR: 0.60, 95 % CI: 0.37 to 0.95), while increases of 10 % in subcutaneous adipose tissue were associated with DFS (HR: 0.59, 95 % CI: 0.36 to 0.95). These results indicate that, although muscle mass and visceral adipose tissue were not associated with DFS or OS, changes in intramuscular and subcutaneous adipose tissue can predict immunotherapy clinical outcomes in patients with advanced lung cancer.
DOI
10.3390/cancers15051382
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Khan, A., Welman, C. J., Abed, A., O’Hanlon, S., Redfern, A., Azim, S., ... & Khattak, A. (2023). Association of computed tomography measures of muscle and adipose tissue and progressive changes throughout treatment with clinical endpoints in patients with advanced lung cancer treated with immune checkpoint inhibitors. Cancers, 15(5), Article 1382. https://doi.org/10.3390/cancers15051382