Myeloid sarcoma: A poorly recognised but important differential diagnosis of epithelioid angiosarcoma

Document Type

Letter to the Editor

Publication Title

Pathology

PubMed ID

36931918

Publisher

Elsevier

School

School of Medical and Health Sciences

Comments

Wong, D. D., Amanuel, R., Chua, Y. J., Hendry, S., Robbins, P., Cheah, C. Y., & Amanuel, B. (2023). Myeloid sarcoma: a poorly recognised but important differential diagnosis of epithelioid angiosarcoma. Pathology, 55(5), 734-738. https://doi.org/10.1016/j.pathol.2022.12.353

Abstract

To the Editor, Epithelioid angiosarcoma is a malignant neoplasm showing endothelial differentiation, distinguished from conventional angiosarcoma by prominent epithelioid cytomorphology. As a result, the differential diagnosis for pathologists is unique and focuses on tumours with predominant epithelioid features. This includes other vascular tumours such as epithelioid haemangioma and epithelioid haemangioendothelioma as well as non-vascular malignant neoplasms such as carcinoma and melanoma. Diagnosis in practice is usually uncomplicated as most examples demonstrate overtly malignant histological findings, allowing separation from benign or borderline vascular tumours. In addition, highly sensitive and specific immunohistochemical markers of endothelial differentiation such as CD31, CD34, ERG and FLI-1, facilitate their distinction from non-vascular mimics.

DOI

10.1016/j.pathol.2022.12.353

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free_to_read

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