Abstract

Purpose: To examine the effects and moderators of exercise effects on cardiometabolic outcomes in men with prostate cancer previously or currently undergoing androgen deprivation therapy (ADT). Results: Seven trials including 560 patients were examined. Exercise resulted in significant effects on whole-body and regional fat mass (P ≤ 0.001). For whole-body fat mass, significant exercise effects were observed in patients who were unmarried (−1.4 kg, P < 0.05) and who presented with higher fat mass levels (−1.0 kg, P < 0.05). For diastolic blood pressure and low-density lipoprotein (LDL), younger (−4.7 mmHg, P < 0.05) and older patients (−0.2 mmol.l-1, P < 0.10) achieved greater effects, respectively. Regarding high-density lipoprotein (HDL), patients undertaking ADT + prostatectomy + radiotherapy derived significant exercise effects (0.3 mmol.l-1, P < 0.05). Conclusions: Exercise effectively reduces fat mass across subgroups of men undergoing or following ADT with different characteristics. For diastolic blood pressure, HDL and LDL, groups based on age and treatment history could be specifically targeted with exercise medicine.

RAS ID

58206

Document Type

Journal Article

Date of Publication

6-1-2023

Volume

186

Funding Information

National Health and Medical Research Council Centre of Research Excellence (CRE) in Prostate Cancer Survivorship Scholarship and Prostate Cancer Survivorship

School

School of Medical and Health Sciences / Exercise Medicine Research Institute

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Publisher

Elsevier

Comments

Lopez, P., Newton, R. U., Taaffe, D. R., Winters-Stone, K., Buffart, L. M., & Galvão, D. A. (2023). Effects and moderators of exercise medicine on cardiometabolic outcomes in men with prostate cancer previously or currently undergoing androgen deprivation therapy: An individual patient data meta-analysis. Critical Reviews in Oncology/Hematology, 186, Article 103995. https://doi.org/10.1016/j.critrevonc.2023.103995

Share

 
COinS
 

Link to publisher version (DOI)

10.1016/j.critrevonc.2023.103995