Document Type

Journal Article

Publication Title

Critical Reviews in Oncology/Hematology

Volume

186

Publisher

Elsevier

School

School of Medical and Health Sciences / Exercise Medicine Research Institute

RAS ID

58206

Funders

National Health and Medical Research Council Centre of Research Excellence (CRE) in Prostate Cancer Survivorship Scholarship and Prostate Cancer Survivorship

Comments

Lopez, P., Newton, R. U., Taaffe, D. R., Winters-Stone, K., Buffart, L. M., & Galvão, D. A. (2023). Effects and moderators of exercise medicine on cardiometabolic outcomes in men with prostate cancer previously or currently undergoing androgen deprivation therapy: An individual patient data meta-analysis. Critical Reviews in Oncology/Hematology, 186, Article 103995. https://doi.org/10.1016/j.critrevonc.2023.103995

Abstract

Purpose: To examine the effects and moderators of exercise effects on cardiometabolic outcomes in men with prostate cancer previously or currently undergoing androgen deprivation therapy (ADT). Results: Seven trials including 560 patients were examined. Exercise resulted in significant effects on whole-body and regional fat mass (P ≤ 0.001). For whole-body fat mass, significant exercise effects were observed in patients who were unmarried (−1.4 kg, P < 0.05) and who presented with higher fat mass levels (−1.0 kg, P < 0.05). For diastolic blood pressure and low-density lipoprotein (LDL), younger (−4.7 mmHg, P < 0.05) and older patients (−0.2 mmol.l-1, P < 0.10) achieved greater effects, respectively. Regarding high-density lipoprotein (HDL), patients undertaking ADT + prostatectomy + radiotherapy derived significant exercise effects (0.3 mmol.l-1, P < 0.05). Conclusions: Exercise effectively reduces fat mass across subgroups of men undergoing or following ADT with different characteristics. For diastolic blood pressure, HDL and LDL, groups based on age and treatment history could be specifically targeted with exercise medicine.

DOI

10.1016/j.critrevonc.2023.103995

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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