Document Type
Journal Article
Publication Title
Nutrition, Metabolism and Cardiovascular Diseases
Volume
33
Issue
6
First Page
1167
Last Page
1178
PubMed ID
36948936
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
57875
Funders
Kræftens Bekæmpelse
Abstract
Background and aims: Polyphenol-rich foods have beneficial properties that may lower cardiometabolic risk. We aimed to prospectively investigate the relationship between intakes of dietary polyphenols, and metabolic syndrome (MetS) and its components, in 676 Danish residents from the MAX study, a subcohort of the Danish Diet, Cancer and Health–Next Generations (DCH-NG) cohort. Methods and results: Dietary data were collected using web-based 24-h dietary recalls over one year (at baseline, and at 6 and 12 months). The Phenol-Explorer database was used to estimate dietary polyphenol intake. Clinical variables were also collected at the same time point. Generalized linear mixed models were used to investigate relationships between polyphenol intake and MetS. Participants had a mean age of 43.9y, a mean total polyphenol intake of 1368 mg/day, and 75 (11.6%) had MetS at baseline. Compared to individuals with MetS in Q1 and after adjusting for age, sex, lifestyle and dietary confounders, those in Q4 – for total polyphenols, flavonoids and phenolic acids–had a 50% [OR (95% CI): 0.50 (0.27, 0.91)], 51% [0.49 (0.26, 0.91)] and 45% [0.55 (0.30, 1.00)] lower odds of MetS, respectively. Higher total polyphenols, flavonoids and phenolic acids intakes as continuous variable were associated with lower risk for elevated systolic blood pressure (SBP) and low high-density lipoprotein cholesterol (HDL-c) (p < 0.05). Conclusions: Total polyphenol, flavonoid and phenolic acid intakes were associated with lower odds of MetS. These intakes were also consistently and significantly associated with a lower risk for higher SBP and lower HDL-c concentrations.
DOI
10.1016/j.numecd.2023.02.022
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Lanuza, F., Zamora-Ros, R., Bondonno, N. P., Meroño, T., Rostgaard-Hansen, A. L., Riccardi, G., ... & Andres-Lacueva, C. (2023). Dietary polyphenols, metabolic syndrome and cardiometabolic risk factors: An observational study based on the DCH-NG subcohort. Nutrition, Metabolism and Cardiovascular Diseases, 33(6), 1167-1178. https://doi.org/10.1016/j.numecd.2023.02.022