A nested case-control study to explore the association between immunoglobulin G N-glycans and ischemic stroke

Abstract

Objective: This study prospectively investigates the association between immunoglobulin G (IgG) N-glycan traits and ischemic stroke (IS) risk. Methods: A nested case-control study was conducted in the China suboptimal health cohort study, which recruited 4,313 individuals in 2013–2014. Cases were identified as patients diagnosed with IS, and controls were 1:1 matched by age and sex with cases. IgG N-glycans in baseline plasma samples were analyzed. Results: A total of 99 IS cases and 99 controls were included, and 24 directly measured glycan peaks (GPs) were separated from IgG N-glycans. In directly measured GPs, GP4, GP9, GP21, GP22, GP23, and GP24 were associated with the risk of IS in men after adjusting for age, waist and hip circumference, obesity, diabetes, hypertension, and dyslipidemia. Derived glycan traits representing decreased galactosylation and sialylation were associated with IS in men (FBG2S2/(FBG2 + FBG2S1 + FBG2S2): odds ratio (OR) = 0.92, 95% confidence interval (CI): 0.87 – 0.97; G1n: OR = 0.74, 95% CI: 0.63 – 0.87; G0n: OR = 1.12, 95% CI: 1.03–1.22). However, these associations were not found among women. Conclusion: This study validated that altered IgG N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.

Document Type

Journal Article

Date of Publication

5-1-2023

Volume

36

Issue

5

PubMed ID

37253665

Publication Title

Biomedical and Environmental Sciences

Publisher

Chinese Center for Disease Control and Prevention

School

School of Medical and Health Sciences / Centre for Precision Health

RAS ID

60236

Funders

National Natural Science Foundation of China (No.81673247, 81872682, 81903401)

Comments

Wang, B. Y., Song, M. S., Zhang, J., Meng, X. N., Xing, W. J., & Wang, Y. X. (2023). A nested case-control study to explore the association between immunoglobulin G N-glycans and ischemic stroke. Biomedical and Environmental Sciences, 36(5), 389-396. https://doi.org/10.3967/bes2023.048

Copyright

free_to_read

First Page

389

Last Page

396

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Link to publisher version (DOI)

10.3967/bes2023.048