Document Type

Journal Article

Publication Title

Glycoconjugate Journal

Volume

40

Issue

4

First Page

413

Last Page

420

PubMed ID

37341803

Publisher

Springer

School

School of Medical and Health Sciences / Centre for Precision Health

RAS ID

58254

Funders

National Natural Science Foundation of China

Comments

This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10719-023-10127-6

Wang, B., Gao, L., Zhang, J., Meng, X., Xu, X., Hou, H., . . . Wang, Y. (2023). Unravelling the genetic causality of immunoglobulin G N-glycans in ischemic stroke. Glycoconjugate Journal, 40(4), 413-420. https://doi.org/10.1007/s10719-023-10127-6

Abstract

Background: Evidence suggests that immunoglobulin G (IgG) N-glycosylation is associated with ischemic stroke (IS). However, the causality of IgG N-glycosylation for IS remains unknown. Methods: Two-sample Mendelian randomization (MR) analyses were performed to investigate the potential causal effects of genetically determined IgG N-glycans on IS using publicly available summarized genetic data from East Asian and European populations. Genetic instruments were used as proxies for IgG N-glycan traits. IgG N-glycans were analysed using ultra-performance liquid chromatography. Four complementary MR methods were performed, including the inverse variance weighted method (IVW), MR‒Egger, weighted median and penalized weighted median. Furthermore, to further test the robustness of the results, MR based on Bayesian model averaging (MR-BMA) was then applied to select and prioritize IgG N-glycan traits as risk factors for IS. Results: After correcting for multiple testing, in two-sample MR analyses, genetically predicted IgG N-glycans were unrelated to IS in both East Asian and European populations, and the results remained consistent and robust in the sensitivity analysis. Moreover, MR-BMA also showed consistent results in both East Asian and European populations. Conclusions: Contrary to observational studies, the study did not provide enough genetic evidence to support the causal associations of genetically predicted IgG N-glycan traits and IS, suggesting that N-glycosylation of IgG might not directly involve in the pathogenesis of IS.

DOI

10.1007/s10719-023-10127-6

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