Gut microbial genetic variation modulates host lifespan, sleep, and motor performance
Document Type
Journal Article
Publication Title
The ISME Journal
Publisher
Nature
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
61941
Funders
National Natural Science Foundation of China / Natural Science Foundation of Jiangsu Province / Xuzhou key research and development plan project / Jiangsu University Students Innovation and Entrepreneurship Training Program
Abstract
Recent studies have shown that gut microorganisms can modulate host lifespan and activities, including sleep quality and motor performance. However, the role of gut microbial genetic variation in regulating host phenotypes remains unclear. In this study, we investigated the links between gut microbial genetic variation and host phenotypes using Saccharomyces cerevisiae and Drosophila melanogaster as research models. Our result suggested a novel role for peroxisome-related genes in yeast in regulating host lifespan and activities by modulating gut oxidative stress. Specifically, we found that deficiency in catalase A (CTA1) in yeast reduced both the sleep duration and lifespan of fruit flies significantly. Furthermore, our research also expanded our understanding of the relationship between sleep and longevity. Using a large sample size and excluding individual genetic background differences, we found that lifespan is associated with sleep duration, but not sleep fragmentation or motor performance. Overall, our study provides novel insights into the role of gut microbial genetic variation in regulating host phenotypes and offers potential new avenues for improving health and longevity.
DOI
10.1038/s41396-023-01478-x
Access Rights
subscription content
Comments
Li, Y., Xu, S., Wang, L., Shi, H., Wang, H., Fang, Z., . . . Zhu, Z. (2023). Gut microbial genetic variation modulates host lifespan, sleep, and motor performance. The ISME Journal, 17, 1733-1740. https://doi.org/10.1038/s41396-023-01478-x