Document Type
Journal Article
Publication Title
BMC Research Notes
Volume
16
Issue
1
Publisher
Springer
School
School of Medical and Health Sciences
RAS ID
64547
Abstract
Objective: Haematological and liver fibrotic markers could be appreciably utilized for effective monitoring of Chronic Hepatitis B viral (HBV) infection, thereby increasing patient’s treatment outcome. The objective of this study was to assess the applicability of complete blood count (CBC) and non-invasive liver-fibrotic indices as markers of prognostic outcome and monitoring in HBV infections. Results: Significant differences in levels of white cell and differentials counts, red blood cell count, hemoglobin indices, and platelet indices were observed between HBV-infected patients (cases) and uninfected persons (controls). Levels of haemoglobin (Hb), total white blood cells (tWBC), neutrophils, monocytes, platelets, and Platelet Distribution width (PDW) were significantly lower (p < 0.05) in the cases compared to the controls. Total and indirect bilirubin; De-Ritis ratio, Aspartate transaminase to platelet ratio index (APRI) and RDW-to-platelet ratio (RPR) were elevated in cases compared with controls (p-value < 0.05). In a multivariate adjusted model to test the significance of markers, Hemoglobin Index (beta coefficient = − 0.876, p-value < 0.001), NLR (beta coefficient = − 0.839, p-value < 0.001), MPV_10000 (beta coefficient = − 0.333, p-value < 0.001) and Albumin (beta coefficient = − 0.059, p-value = 0.014), were associated with HBV infection status. Receiver operative characteristics curve analysis showed Hemoglobin Index (AUC = 0.744) and MPV_10000 (AUC = 0.730) as better prognostic markers for HBV-infection.
DOI
10.1186/s13104-023-06581-y
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Nyarko, E. N. Y., Obirikorang, C., Owiredu, W. K. B. A., Adu, E. A., & Acheampong, E. (2023). Assessment of the performance of haematological and non-invasive fibrotic indices for the monitoring of chronic HBV infection: A pilot study in a Ghanaian population. BMC Research Notes, 16, article 312. https://doi.org/10.1186/s13104-023-06581-y